In the present investigation, an attempt was made to improve the dissolution properties of famotidine, by utilizing liquisolid technique, which might offer improved bioavailability. The prepared famotidine liquisolid powder were prepared using polyethyleneglycol 200 and cremophor®RH40, as the liquid vehicle. Avicel® PH101 and aerosil® 200, were used as carrier and coating material, respectively. Effect of changing carrier:coat ratio was studied. The degree of crystallinity of the newly formulated famotidine liquisolid powder was examined by differential scanning calorimetry and fourier transform infrared spectroscopy (FT-IR). Percent drug dissolved and powder flowability was assessed. The results showed a higher dissolution rates ranging from 81.3% to 98.1% after 2 mins with acceptable flowability.
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